Journal of Medical Research and Innovation https://jmri.org.in/jmri <p style="text-align: justify;">The <em><strong>Journal of Medical Research and Innovation</strong></em>&nbsp;is an open peer-reviewed, clinically oriented journal covering all aspects of Medicine including cellular biology, zoology and futuristic medicine (Robotics and Artificial Intelligence in medicine). The journal will feature original research, reviews, editorials, case studies, Brief Communications, Opinions/Views, Poster Presentations and Audios and Videos. This will be of interest to medical practitioners, clinical educators, nurse practitioners and other health care professionals involved in the care of patients.</p> JMRI Publications en-US Journal of Medical Research and Innovation 2456-8139 A Comparative Study of Endoscopic Finding and Radiological Appearance in Paranasal Sinus Disease https://jmri.org.in/jmri/article/view/128 <p><strong>Aims and Objectives:</strong>&nbsp;The study is carried out with an objective to compare the diagnostic nasal endoscopic findings and radiological appearance in patients with paranasal sinus disease.</p> <p><strong>Methods:&nbsp;</strong>50 cases of chronic sinusitis not responding to routine medical line of treatment were selected and operated after being thoroughly investigated by means of nasal endoscopy and CT scan.&nbsp;</p> <p><strong>Results:&nbsp;</strong>Out of 50 cases, 35 underwent bilateral surgery and 15 underwent unilateral surgery, so a total of 85 procedures were carried out. Findings of both the CT scan as well as diagnostic nasal endoscopy were compared to each other and ultimately correlated with operative findings.&nbsp;</p> <p><strong>Conclusion:</strong> In our study, a high association is found between both the modalities of investigation i.e CT scan and diagnostic nasal endoscopy with one scoring over the other in different parameters. Diagnostic nasal endoscopy is found to be highly sensitive investigatory modality for parameters like frontal recess, spheno-ethmoid recess and hiatus semilunaris, where as CT scan is found to be highly sensitive for parameters like maxillary sinus, uncinate process and posterior ethmoids. So, a case of sinus disease should be diagnosed as early as possible using both these modalities as together they complement each other. Early diagnosis and effective management cures the pathology and prevents disastrous complications.</p> <p>&nbsp;</p> Anjani Agarwal Alpesh Fefar Manish Mehta ##submission.copyrightStatement## http://creativecommons.org/licenses/by-nc-nd/4.0 2018-05-11 2018-05-11 2 1 e000128 e000128 10.15419/jmri.128 Study of Myocardial Dysfunction in Perinatal Asphyxia Field https://jmri.org.in/jmri/article/view/127 <p><strong>Aims and Objectives:</strong>&nbsp;To study an incidence of myocardial dysfunction in neonates admitted with perinatal asphyxia, to find out its correlation with severity of birth asphyxia and its outcome.</p> <p><strong>Methods:</strong>&nbsp;This prospective study was conducted among 40 term neonates admitted in NICU of Civil Hospital Ahmedabad who had suffered with perinatal asphyxia (defined by WHO ), resuscitated as per NRP guidelines-2015 including both intramural and extramural admissions and who developed to hypoxic ischemic encephalopathy as defined by Levene staging. Neonates with congenital heart diseases, major central nervous system malformations and neonatal sepsis were excluded. Myocardial involvement was assessed by clinical evaluation, ECG, Creatinine Kinase Total (25-200IU/L), CK-MB (0-25IU/L) and Troponin I (0-0.03ug/L) measurements.</p> <p><strong>Results:&nbsp;</strong>Among 40 cases, 10(25%) neonates had moderate birth asphyxia while 30(75%) had severe birth asphyxia. Respiratory distress was observed in 34(77.5%), poor spontaneous respiration 4(10%),shock in 14(35%),CCF 19(47.5%) while ECG was abnormal in 30(76.7%). Serum levels of CPK Total, CPK- MB and Troponin I were raised in 34(85%), 32(80%) and 28 (70%) neonates, respectively.&nbsp;</p> <p><strong>Conclusion</strong>:&nbsp;There was a direct correlation between ECG changes and enzymatic levels which showed increasing abnormalities with increasing with severity of HIE.</p> <p>&nbsp;</p> kushali Tanna K M Mehariya Suchita Munsi Charul Pujani ##submission.copyrightStatement## http://creativecommons.org/licenses/by-nc-nd/4.0 2018-05-10 2018-05-10 2 1 e000127 e000127 10.15419/jmri.127 A Study of Neurological Deficits in Survived Cases of Diphtheria https://jmri.org.in/jmri/article/view/126 <p><strong>Aims and Objectives:&nbsp;</strong>To study the incidence, clinical profile and outcome of children with diphtheritic neuropathy.</p> <p><strong>Methodology:&nbsp;</strong>A retrospective study of 26 patients with clinical diagnosis of post diphtheritic neuropathy was done. The records were reviewed and information regarding demographic profile, immunization status, clinical presentation, treatment received (medical &amp;/ or surgical including ventilator care) &amp; the outcome were recorded in pro-forma. The results were tabulated and analysed. All the cases who had whitish grey adherent membrane and evidence of neck swelling or has laboratory confirmed evidence (smear or culture positive cases) were diagnosed as cases of diphtheria and amongst them who developed features of neurological deficits like bulbar palsy, cranial nerve involvement or limb weakness were enrolled for further information amongst the survived cases of diphtheria. Patients with other evident cause for neurological deficit were excluded. During this time period total 138 patients of diphtheria were admitted at our hospital and among them 38 patients expired due to various complications.&nbsp;</p> <p><strong>Results:&nbsp;</strong>Incidence of Diphtheritic neuropathy was 29.8% among survived cases of diphtheria in our study. Median age of presentation was 7 years and Median latency period was 18 days. Among these patients 96% patients were either partially immunised or unimmunized. All of them had features of bulbar palsy. Isolated palatal palsy was most common presentation and was present in 53.84% patients. GBS like illness was present in 4 (15.38%) patients. Cranial nerve involvement was present in 8% of patients. Full recovery was seen in 30.7% and partial recovery was seen in 46.15% of patients. Boys were more in numbers.</p> <p><strong>Conclusion:</strong> Diphtheria is a vaccine preventable disease so, routine vaccine administration, prompt diagnosis, early treatment, early administration of ADS and early recognition of complications and treatment of such will reduce associated morbidity and mortality.</p> Twinkle Patel Chirag Shah ##submission.copyrightStatement## http://creativecommons.org/licenses/by-nc-nd/4.0 2018-05-10 2018-05-10 2 1 e000126 e000126 10.15419/jmri.126 A Clinical Study and Management of Inguino-scrotal Swellings In Children https://jmri.org.in/jmri/article/view/125 <p><strong>Aims and Objectives:</strong>&nbsp;To know the most common surgical problems in pediatric patients presented with inguino-scrotal swellings and management done routinely.</p> <p><strong>Methodology:&nbsp;</strong>This study was carried out in the department of general surgery, Sharadaben hospital and pediatric surgery of VS hospital, Ahmedabad. The cases were studied for a period of about one year (January, 2017 to Dec, 2017) and all children below 12 years of age, presenting to us with inguinoscrotal swellings were included in this study. The information was analysed in terms of age, diagnosis, procedure carried out and outcome.</p> <p><strong>Results:&nbsp;</strong>Amongst the 150 children under the age of 12 years, 143 patients were males and 7 were females. Among these 150, 52 cases were of hydrocoele, 70 cases of hernia (of which 63 were males and 7 were females), 25 cases of undescended testis and 3 cases of epididymo orchitis were documented. All cases underwent simple herniotomy for hernia and hydrocoele, orchidopexy for undescended testis. The length of hospital stay ranged from 2-4 days with mean of 2.46 days. 11 children in the study were documented to have short term complications, all of which were recognised in the hospital and managed with good results.</p> <p><strong>Conclusion:&nbsp;</strong>Hernia and Hydrocoele in children are often congenital and diagnosed clinically (history and examination). Indirect inguinal hernia are more common than other groin hernias. Open herniotomy is the operation of choice for inguinal hernia in children.</p> Khyati Vaja Mukesh Suvera ##submission.copyrightStatement## http://creativecommons.org/licenses/by-nc-nd/4.0 2018-05-10 2018-05-10 2 1 e000125 e000125 10.15419/jmri.125 A Rare Pulmonary Manisfestation of Kahler's disease https://jmri.org.in/jmri/article/view/115 <p>Kahler's disease also known as Multiple Myeloma (MM) is one of the most dangerous primary malignancy of the bone marrow which is significant for its plasma cells proliferation and abnormal growth of monoclonal immunoglobulins (including M protein and light chain proteins: κ and λ). Excess amount of M protein is a potential blood thickener due to its effects on viscosity, while an excess amount of light chains could lead to an end-organ damage.</p> <p>MM presenting as Interstital Lung Disease (ILD) has been documented in very rare occasions till date and hence, we are presenting forward a letter showing the importance of considering MM as a differential when a patient presents with ILD features by presenting one such case of a patient who was diagnosed with MM and developed ILD secondary due to infiltration of Myeloma cells in the parenchyma of the lungs.</p> Gaurav Baheti Ankur Jain ##submission.copyrightStatement## http://creativecommons.org/licenses/by/4.0 2018-04-20 2018-04-20 2 1 e000115 e000115 10.15419/jmri.115