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Abstract

Alzheimer’s disease (AD) is a chronic and slowly progressing neurodegenerative disorder which has become a major health concern worldwide. The literature has shown that oxidative stress is one of the most important risk factors behind the cause of AD. Oxidative stress often leads to the production of Reactive Oxygen Species (ROS).


D-Galactose, a physiological nutrient and reducing sugar, non-enzymatically reacts with amines of amino acids in proteins and peptides to form Advanced Glycation End products which activate its receptors coupled to Biochemical pathways that stimulate free radical production and induces mitochondrial dysfunction which damages the neuron intracellularly. High dosage of D-Galactose also suppresses the expression of nerve growth factors and its associated protein which results in the degeneration of nerve cells and reduction of acetylcholine levels in brain regions.


This article put forwards the advantages of using Lactic Acid Bacteria (Probiotics) possessing anti-oxidant properties and which produces Acetyl Choline against D-Galactose induced Alzheimer’s disease.


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Article Details

Issue: Vol 1 No 1 (2017)
Page No.: 30-33
Section: Articles
DOI: https://doi.org/10.15419/jmri.15

Publication history
Received: 30-01-2017
Accepted: 26-02-2017
Published: 04-03-2017


 License and Copyright Info
 Copyright 2017. Varshil Mehta, Kavya Bhatt, Nimit Desai, Mansi Naik.


 How to Cite
1.
Mehta V, Bhatt K, Desai N, Naik M. Probiotics: An Adjuvant therapy for D-Galactose induced Alzheimer’s disease. Journal of Medical Research and Innovation. 2017;1(1):30-3. DOI: 10.15419/jmri.15

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