Diabetes mellitus is a chronic disorder of carbohydrate, protein and lipid metabolism that leads to vascular complications resulting in morbidity and even mortality . Type 2 diabetes often manifests in the adulthood, generally, in those who are obese and leading a sedentary life style .
Common symptoms associated with the disease are frequent urination, weight loss, lack of energy (lethargy) and excessive thirst . Biochemical examination of blood indicates high levels of blood glucose (hyperglycemia) .
Hyperglycemia can be controlled by administrating drugs which work on different principles, but ends with some side effects [5, 6]. Therefore, controlling by diet and lifestyle modification is advocated .
Once hyperglycemia is noted in a patient, the immediate advice that follows would be to reduce or avoid free sugar in the diet. Depending on the severity of the hyperglycemia, even carbohydrate is also restricted. Any inhibition or withdrawal of food from a patient puts him in an intimidating position, especially, in a social gathering.
Against such a backdrop, we report here a case study of a patient, who managed hyperglycemia through life style modifications. The patient was taking normal Indian food along with a bowel of wheat porridge during breakfast and dinner. Lunch consisted of usual diet without any wheat porridge. His work demanded moving about and he used to walk at least 2 Km in a day. With this type of lifestyle, the results reported here is encouraging to diabetic patients and warrants further study in a larger population.
The patient was declared diabetic on 25/6/2011 based on the biochemical reports, which indicated hyperglycemia in the blood and presence of sugar in the urine. He was advised to take medicines to control hyperglycemia. Since his hunger pangs increased on medications, the dose was tapered and discontinued. He decided to restrict carbohydrate in his diet and to do moderate exercises like walking. These modifications helped him to bring down the glucose level to 250 mg/dl within a month’s time. However, he was on Losar 50, one tablet a day for his hypertension.
Meanwhile, he looked into the history of diabetics in his family. His grandfather, an active person with moderate intake of food, did not have any diabetics in his life. However, his grandmother, a house wife and an obese person, was a diabetic patient. They had eight children and seven of them had diabetics at some stage of their adult life. One offspring did not have any diabetics. The diet habits of all the children were recorded. Then it was found that the non-diabetic offspring included wheat porridge daily in his breakfast while others took normal food for their breakfast. The breakfast of non-diabetic person included wheat porridge with milk, sugar or jaggery syrup along with one or two sandwiches stuffed with fillings made of legumes.
Management and Outcome
Based on the above findings, the patient included wheat porridge in his breakfast. Wheat porridge was made with wheat particles obtained by grinding wheat coarsely and different particle sizes of wheat were tried for making the porridge. According to Bureau of Indian Standards (BIS), wheat particles should be between 300 µm and 850 µm . After trying different particle sizes, it was found that inclusion of particles lower than 300 µm gave a better result in eliminating the symptoms of the disease and hunger pangs. The porridge made from these particles gave good satiety. Similar observations are reported earlier . Since these sizes are not included as porridge by BIS, we labeled it as a proprietary food.
Wheat particles were roasted and the nutrient compositions of the ready to cook particles are given in table 1. It was analyzed in a NABL accredited laboratory (Varni Labs, Mira Road, Mumbai, reference, VAL/TC/17020499 & VAL/TC/1704/0306).
|Sr. No.||Nutritional component||Quantity per 100g sample|
|4||Energy||395.9 k Cal|
|5||Total sugar||4.6 g|
|6||Total Dietary fiber||2.3g|
When the patient had only porridge for the breakfast, he felt cravings for tea with sugar at around 11 am. In order to overcome this habit, some amount of normal food was also included with wheat porridge during the breakfast. This eliminated the cravings for tea.
Symptoms of diabetics were reduced in the patient after taking wheat porridge (table 2). Later on, he included wheat porridge in the dinner, as a desert, with addition of one or two teaspoons of sugar. This pattern of diet was continued for months. The intake of free sugar was not stopped but used moderately.
|Symptoms||In the initial stage before wheat porridge was taken||Three months after wheat porridge was taken|
|Hunger pangs, Cravings for snacking etc.||Very high||Reduced to normal eating habits|
|Urination frequency especially in the night||High. At least 4 times in the night.||Only 1 – 2 times in the night|
|Sleep pattern||Disturbed with dreams.||Sound sleep of at least 3-4 hours|
|Feeling of tiredness (fatigue)||High with aches in the muscles.||Much reduced|
|Lethargy to do work||Very high||Low|
|Tendency to take nap after lunch||High||No, if moderate amount of food is consumed.|
After taking the above diet for more than 3 months, the postprandial glucose and HbA1c status of the blood and presence of sugar and ketone bodies in the urine were analyzed (Table 3). The status of postprandial level of glucose and the presence of sugar in the urine at the onset of disease in 2011 is also given in the (table 3).
|Sr. No.||Year||Blood glucose (mg/dl)||Presence of sugar in the urine||Ketone bodies||HbA1c||eAG (mg/dl)|
|1.||2011||306.8||+ + +||-||-||-|
In order to confirm the effect of wheat porridge on the postprandial glucose level, the intake of porridge was stopped for about 7 days and the glucose level was measured. The postprandial glucose increased to 231.4 mg/dl (table 4).
|Sr. No.||Conditions||Blood glucose (mg/dl)||Presence of glucose in the urine||Presence of ketone bodies in the urine|
|1.||Without wheat porridge for 7 days.||231.4 (n=3)||+ + +||-|
|2.||After restarting of wheat porridge diet.||197.5 (n=2)||-||-|
|3.||After taking composite wheat porridge given in Table 5.||163.5 (n=2)||-||-|
After taking the glucose reading for 3 days, wheat porridge was again included in the diet. The postprandial glucose was measured and the average level was 197.5 mg/dl. In order to bring down the blood glucose, a composite wheat porridge explained by Ahmed & Urooj (2015) was used with modification. Instead of oats we used black gram powder. Black gram is a legume and it is normally available in Indian homes. The composition of the composite wheat porridge is given below (table 5).
|1.||Roasted wheat porridge granules||3 table spoons (45 g)|
|2.||Psyllium husk||½ teaspoon (2-3 g)|
|3.||Black gram powder||1 teaspoon (5g)|
|4.||Salt||A pinch for the taste|
Instead of psyllium husk, a small piece of okra cut into small pieces can be used to increase the mucilage in the porridge. After taking the composite wheat porridge the postprandial glucose level was in the range of 150-170 mg/dl as shown in Table 3. When the postprandial glucose was in 150 -160 mg/dl range, the composite wheat porridge was replaced with plain wheat porridge along with side dish made of vegetables or legumes.
“Whole wheat contains intact cereal germ, endosperm and bran.”  Intake of whole grain was beneficial to health as reported in many epidemiological studies . The population that consumed whole grain had lower Body Mass Index (BMI) , lower incidence of Type 2 diabetes , cardiovascular disease  and colorectal cancer . Whole grain diet also reduced the risk of mortality .
Wheat porridge, a whole grain meal, has distinct physico-chemical properties. “The amount of insoluble fiber, resistant starch, phytochemicals, granular size, porosity, the interaction of starch and protein within the structural matrix may influence in the digestion and absorption of carbohydrates” . “Wheat has predominantly insoluble fiber and less amount of soluble fiber like β-glucan” . The amount of dietary fiber in the porridge was low (table 1). However, the soluble fibers from other food may also influence the matrix.
Wheat porridge becomes viscous due to gel formation and this property may slow down the amylase activity on the consumed food. Viscous gel formation also delays gastric emptying and this may have reduced hunger pangs (table 2).
In the present case study inclusion of wheat granules less than 300 µm alleviated the symptoms better and showed lower postprandial glucose in the blood. Actually the amylase activity is expected to be high in smaller granules resulting in hyperglycemia due rapid digestion and absorption. However, in the present study such effect was noted. This may be due to the small size of insoluble fiber in the matrix. As the size of insoluble fiber decreases, the surface area increases . The increased surface areas may facilitate adsorption of glucose, formed during amylase activity . The binding of glucose may have inhibited diffusion of glucose in the intestine [1, 9]. Apart from the adsorption of glucose by insoluble fiber, the viscosity of wheat porridge may have delayed the amylase activity as explained above.
“Low postprandial glycaemia during breakfast has its effect on the following second meal like lunch” . The low postprandial glycaemia in the present case study may have reduced oxidative stress in the patient. Oxidative stress initiates cytokine production which impairs insulin signaling . Therefore, under the low oxidative stress and with less cytokine production, the attenuation of insulin resistance may have promoted better metabolism leading to alleviation of symptoms (table 1).
Regular exercise like walking may have contributed to the alleviation of symptoms because contraction-induced glucose uptake occurs through activation of parallel but distinct insulin-independent pathways .
The present case study has its limitations. However, it deserves some attention because the present case study was carried for more than 2 years and the results obtained are consistent and encouraging. This study supports the suggestions made by Aune et al (2013), ‘to include at least two servings of whole grains per day in the diet to reduce type 2 diabetes risk . Wheat porridge, a whole grain meal, is easy for the patients to make and hence can be included in their diet. It can be taken along with side dish with vegetables and legumes to compensate low soluble fibers in the wheat.
In the light of the present case study, following studies are warranted.
The study presented here needs to be carried out on a larger population of diabetic patients to confirm the findings.
Efforts are directed to study the glucose adsorption; glucose diffusion and amylase kinetics of different granular size of wheat under different conditions.
It was intriguing to observe an increase in protein level (14.0 g%) in the roasted wheat granules. Normally it is around 11g% in the whole wheat flour Wheat porridge is prepared by roasting and during the heat treatment Maillard reaction takes place between amino acids and sugars. The increased protein content may be due to breakdown of complex protein molecules into digestible proteins by heat treatment. Similar observations are reported recently . This observation is important in the efforts to combat malnourishment in the population. If protein content could be increased by simple heat treatment, then it should be adopted in all the feeding programs of children. The SAT mix developed by Sree Avittam Thirunal Hospital in Trivandrum to feed the infants and children. They used roasted grain (wheat) and legumes (green gram and black gram) in equal proportions . The diet was a great success to reduce malnourishment among children in Kerala. The present observation of increased protein content after roasting warrants further research on the quantity and quality of protein along with amino acids in the SAT mix.
When composite wheat porridge was included in the diet, the postprandial glucose was comparatively low. It was observed that the urine was almost colourless while the stool was dark in colour, indicating the increased sequestration of bile salts in the faeces. Hence lipid profile was carried out after taking the composite wheat porridge for two weeks.
The total serum cholesterol - 215.mg/dl
HDL - 45 mg/dl
LDL - 145 mg/dl
Triglycerides - 126 mg/d
The Cholesterol-HDLC ratio was 4.8:1.
The patient had a history of total cholesterol of 240 mg/dl and his HDL was never higher than 38 mg/dl. The ratio of cholesterol was above 5.6. Based on this observation, the cholesterol lowering effect of composite wheat porridge in hyperlipidemia patients need to be carried out to confirm the observation.
Since lipid metabolism is influenced by composite wheat porridge, it is worth looking into its effects in patients with fatty liver, high serum creatinine in Chronic Kidney Disease (CKD) and elevated uric acid in gout disease
The present case study indicates the protective role of wheat porridge in lowering the postprandial glucose in a diabetic patient. Diet modification can play a great role in controlling the disease. Here is another case of science meeting the traditional wisdom, the wisdom quoted by Hippocrates- “Let food be thy medicine…”
The author (patient in the present case study) is indebted to his father Mr. M.E. Eapen, living in Syracuse, USA, for showing a diet through his own experience and for his encouragement and support for the present case study. Therefore this publication is dedicated to him as a gift for his 90th birthday.
Dr. Jitendra Mulky MD (pathology) of Mahalakshmi Laboratories, Kety Nagar, Dahanu Road is acknowledged for biochemical analysis of the blood.
- Ahmed F, Urooj A. In vitro hypoglycemic effects and starch digestibility characteristics of wheat based composite functional flour for diabetics. Journal of food science and technology. 2015;52(7):4530-6. View Article Google Scholar
- Olokoba AB, Obateru OA, Olokoba LB. Type 2 diabetes mellitus: a review of current trends. Oman Med J. 2012;27(4):269-73. View Article Google Scholar
- Ramachandran A. Know the signs and symptoms of diabetes. The Indian journal of medical research. 2014;140(5):579. View Article Google Scholar
- Ahmed F, Sairam S, Urooj A. In vitro hypoglycemic effects of selected dietary fiber sources. Journal of food science and technology. 2011;48(3):285-9. View Article Google Scholar
- Stein SA, Lamos EM, Davis SN. A review of the efficacy and safety of oral antidiabetic drugs. Expert opinion on drug safety. 2013;12(2):153-75. View Article Google Scholar
- McFarlane SI. Antidiabetic medications and weight gain: implications for the practicing physician. Current diabetes reports. 2009;9(3):249-54. View Article Google Scholar
- IS10769.Wheat Porridge: FAD 16: Food grains, starches and ready to eat foods. Wheat Porridge: FAD 16: Food grains, starches and ready to eat foods. ;:. View Article Google Scholar
- Banu H, Itagi N, Jayadeep A, Singh V. Nutrients, Nutraceuticals and Bioactive Properties of Multi-Whole Grain Mix for Drink and Porridge. Journal of Nutritional Therapeutics. 2013;1(2):161-71. View Article Google Scholar
- Higgins JA. Whole grains, legumes, and the subsequent meal effect: implications for blood glucose control and the role of fermentation. Journal of nutrition and metabolism. 2011;2012:829238. View Article Google Scholar
- McKeown NM, Meigs JB, Liu S, Wilson PW, Jacques PF. Whole-grain intake is favorably associated with metabolic risk factors for type 2 diabetes and cardiovascular disease in the Framingham Offspring Study. The American journal of clinical nutrition. 2002;76(2):390-8. View Article Google Scholar
- Flight I, Clifton P. Cereal grains and legumes in the prevention of coronary heart disease and stroke: a review of the literature. European journal of clinical nutrition. 2006;60(10):1145-59. View Article Google Scholar
- Randi G, Edefonti V, Ferraroni M, La Vecchia C, Decarli A. Dietary patterns and the risk of colorectal cancer and adenomas. Nutrition reviews. 2010;68(7):389-408. View Article Google Scholar
- Wu H, Flint AJ, Qi Q, Van Dam RM, Sampson LA, Rimm EB, Holmes MD, Willett WC, Hu FB, Sun Q. Association between dietary whole grain intake and risk of mortality: two large prospective studies in US men and women. JAMA internal medicine. 2015;175(3):373-84. View Article Google Scholar
- Lulashnyk Lorne.Understanding surfaces. Understanding surfaces. 2016;:. View Article Google Scholar
- Richter EA1, Hargreaves M. Exercise, GLUT4, and skeletal muscle glucose uptake. Physiol Rev. 2013;93(3):993-1017. View Article Google Scholar
- Aune D, Norat T, Romundstad P, Vatten LJ. Whole grain and refined grain consumption and the risk of type 2 diabetes: a systematic review and dose–response meta-analysis of cohort studies. European journal of epidemiology. 2013;28(11):845-58. View Article Google Scholar
- Kavitha S, Parimalavalli R. Effect of processing methods on proximate composition of cereal and legume flours. Journal of Human Nutrition and Food Science. 2014;2(4):1051. View Article Google Scholar
- Elizabeth KE, Sreedevi P, Narayanan SN. Outcome of nutritional rehabilitation with and without zinc supplementation. Indian pediatrics. 2000;37(6):650-5. View Article Google Scholar